Some people, however, seem able to cope better than others and the one thing that carries them through the tough times, more than anything else, is their sense that behind all the unfairness of life there is a core of meaning to their existence – something to live for that is above and beyond the problems they are tackling. They rely on this foundation of meaning to carry them through, round or over any obstacle, whatever emotional turbulence it is causing them. Someone with meaning in their life therefore has a high level of psychological robustness – which they can use to weather the storms of life, with all its ups and downs, sadness and loss that happens to everybody at some point.
Since the 1930s, ibogaine was sold in France in 8 mg tablets in the form of Lambarène , an extract of the Tabernanthe manii plant. 8 mg of ibogaine could be considered a microdose since doses in ibogatherapy and -rituals vary in the range of 10 mg/kg to 30 mg/kg adding usually up to 1000 mg.  Lambarène was advertised as a mental and physical stimulant and was "...indicated in cases of depression, asthenia, in convalescence, infectious disease, [and] greater than normal physical or mental efforts by healthy individuals". The drug enjoyed some popularity among post World War II athletes, but was eventually removed from the market, when the sale of ibogaine-containing products was prohibited in 1966.  In the end of 1960's The International Olympic Committee banned ibogaine as a potential doping agent.  Other psychedelics have also been reported to have been used in similar way as doping.