Drugs that help one kind may help the other, but there is a clear difference; no drug works for everybody with any form of mental illness (or hypertension or heart disease). Humans are heterogeneous genetically and culturally. However, we’ve suspected for some time that GSK-3b (glycogen synthase kinase) had something to do with major psychoses and DISC1 (disrupted in schizophrenia) cropped up ten years ago. We now have data linking those two genetic factors (see Ross & Margolis, Nature 458:976, 2009). How to synthesize the paradox that one psychotic mode (Sch) is progressive, associated with impaired neurogenesis and evidence of remote inflammation and the other is not, yet both show are linked to the same gene networks? Human social function requires complex CNS networks. Mental illness is heterogeneous, drug companies are manipulators, but we are making progress.
Optogenetic Analysis of Neural Circuits and Behavior in Zebrafish: Monday, November 20, 2017, 12:00 .