Sculpey is a brand of polymer clay made by Polyform Products in the United States. Sculpey was first created in the early 1960s. The original idea was to use the clay as a thermal transfer compound; this would conduct heat away from the cores of electrical transformers. However, the compound was not successful for this use so it was pushed to the side for a while. In the late 1960s it was then discovered that this compound could be molded, baked, sanded, drilled, carved and painted. This was a perfect medium for the craft industry. The clay was marketed directly to people at craft shows, street fairs and demonstrations in small art stores.
In hypokalemic periodic paralysis (HOKPP), the voltage sensors in domains 2 and 4 of Ca v are mutated (loss-of-function), reducing the availability of the channel to sense depolarisation, and therefore it cannot activate the ryanodine receptor as efficiently. As a result, the muscle cannot contract very well and the patient is paralysed. The condition is hypokalemic because a low extracellular potassium ion concentration will cause the muscle to repolarise to the resting potential more quickly, so any calcium conductance that does occur cannot be sustained. It becomes more difficult to reach the threshold at which the muscle can contract, and even if this is reached then the muscle is more prone to relaxing. Because of this, the severity would be reduced if potassium ion concentrations are maintained. In contrast, hyperkalemic periodic paralysis refers to gain-of-function mutations in sodium channels that maintain muscle depolarisation and therefore are aggravated by high potassium ion concentrations.