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The system is simple, as it only requires a Cas nuclease and a gRNA against the target sequence to function as a site-specific nuclease. Also, despite the bacterial evolutionary origins of the system, data demonstrates high levels of cutting activity in mammalian cells ( Cong et al., 2013 ; Mali et al., 2013 ), particularly at numerous simultaneous targets, ( Wang et al., 2013 ). In addition, the requirement for an NGG sequence makes target design simple and straightforward in genomic regions where off-targeting is not an issue. Finally, CRISPR provides researchers a fast and cost-effective genome editing tool to use for modifying the genomes of various organisms.

If you ever make a change that gets reverted by another editor, discuss the change on the talk page ! The BOLD, revert, discuss cycle is a popular method of reaching consensus, and may be useful for identifying objections, keeping discussion moving forward and helping to break deadlocks. Edit warring (repeatedly overriding or reimplementing contributions) is highly discouraged. There is a bright-line rule called the three-revert rule , the violation of which may lead someone to be blocked from editing to prevent further disruption. Disruptive editing is not always intentional, as new editors may simply not understand the ins and outs of Wikipedia .

There are more video editing software applications than we can fit into this roundup of the best options, which includes only software rated three stars and above. The best known among them is probably Vegas Movie Studio , which was recently acquired by Magix from Sony. Sony's product used a very cluttered interface that more resembled high-end professional video editing software from the early days of the craft. Magix has made some progress in simplifying it and bringing it up to par with the competition, but more work is needed for it to be included here. Another program, VSDC Video Editor Pro , simply has too outdated an interface, making common tasks difficult. There are a couple more interesting applications—NCH VideoPad and AVS Video Editor among them—that we simply haven't tested yet, but plan to put through their paces later this year.

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